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Prostate Cancer( 1)

Metastatic Prostate Cancer ( 2)

The First PartBasic Knowledge of Metastatic Prostate Cancer

What Is Metastatic Prostate Cancer

If your prostate cancer spreads to other parts of your body, that it's "metastatic" or that your cancer has "metastasized."

There are two types of metastatic prostate cancer:

1) Local metastasis: Prostate cancer with local metastasis means that the cancer has spread to other organs within the pelvis. This usually means the local lymph nodes, but can include any organ or structure in the pelvis.

2) Distant metastasis: Distant metastasis means that the prostate cancer has spread beyond the pelvis. The bones, spine, brain, liver, and lungs are common sites of cancer metastasis.

It's still prostate cancer, even when it spreads. For example, metastatic prostate cancer in a bone in your hip is not bone cancer. It has the same prostate cancer cells the original tumor had.

Metastatic prostate cancer is an advanced form of cancer. There's no cure, but you can treat it and control it. Most men with advanced prostate cancer live a normal life for many years.

The goals of treatment are to:

1) Manage symptoms.

2) Slow the rate your cancer grows.

3) Shrink the tumor.

How Prostate Cancer Spreads

Cancer cells sometimes break away from the original tumor and go to a blood or lymph vessel. Once there, they move through your body. The cells stop in capillaries -- tiny blood vessels -- at some distant location.

The cells then break through the wall of the blood vessel and attach to whatever tissue they find. They multiply and grow new blood vessels to bring nutrients to the new tumor. Prostate cancer prefers to grow in specific areas, such as lymph nodes or in the ribs, pelvic bones, and spine.

Most break-away cancer cells form new tumors. Many others don't survive in the bloodstream. Some die at the site of the new tissue. Others may lie inactive for years or never become active.

Why the prostate cancer is prone to bone metastasis?

The symptoms of prostate cancer at the early stage are not too obvious, with about 30% of patients having had the cancer spread at the time of their diagnosis, and 70% of them having had bone metastases, which usually occurs in multiple parts, with only 10% of the metastatic patients in a single part.

Bone metastasis occurs mostly in the middle axle bone, such as the vertebrae and pelvis, accounting for about 80% of bone metastasis, followed by ribs, femur, and humerus.

The Clinical data show that in our body, every gram of tumor tissues can release 3 to 4 million cancer cells into the blood per day, but most of them will be cleared away by immune cells in the blood. On the one hand, the bone has very rich blood circulation, and on the other hand, the arteries and veins of the bone are widely matched; and the diameter of the vein network is also large with fast blood supply, so the cancer cells easily enter the bone cavity. Most of bone metastases occur in the red bone marrow of the central axis, where the blood flow is abundant and slow, so cancer cells that are not cleared away by immune cells tend to stay in these parts, forming metastases.

1) The first symptom of bone metastasis of prostate cancer is most of patients will have bone pain as long as bone metastasis occurs, and this pain will continue to be dull and painful, so the daily life of the patients will be affected.

2) The second symptom of bone metastasis of prostate cancer is cancer cells will destroy the hematopoietic stem cells of red blood marrow, and patients will have such symptoms as anemia, weight loss, low fever, fatigue, and loss of appetite, etc.

3) The third symptom of bone metastasis of prostate cancer is after the patient has bone metastasis, the cancer cells will erode the bone little by little, and the bone will become more and more fragile, prone to have pathological fracture. Fracture has a significant relationship with the bone metastase lesion accounting for the proportion/size of bone diameter. When the bone metastasis lesions are more than 2/3 of the bone diameter, the incidence of fractures can reach 81%. If the cancer cells get further transferred, they will be spread to the spine, and the collapse of the centrum will cause the symptom of spinal cord to be compressed, which makes treatment become very difficult.

How Doctors Find Metastatic Prostate Cancer

When you are diagnosed with prostate cancer, your doctor will order tests such as:

X-raysCT scans;MRI scans;PET scans.

These tests may focus on your skeleton and in your belly and pelvic areas. That way doctors can check for signs that the cancer has spread.

If you have symptoms such as bone pain and broken bones for no reason, your doctor may order a bone scan. It can show if you have metastatic cancer in your bones.

Your doctor will also ask for blood tests, including a check of PSA levels, to look for other signs that the cancer is spreading.

PSA is a protein made by the prostate gland. A rise in PSA is one of the first signs your cancer may be growing. But PSA levels can also be high without there being cancer, such as if you have an enlarged prostate or a prostate infection.

On average, 8 years pass from the time a man is first diagnosed with prostate cancer to the discovery that it has become metastatic. If you've had prostate cancer, work with your doctor to check your risk and set a schedule for routine PSA checks.

Metastatic Prostate Cancer Symptoms

Man experiencing painful urination because of a prostate problem. Potential symptoms of prostate cancer include difficulty urinating, pain during urination, and a sense of needing to urinate urgently.

Symptoms of prostate cancer can include:urinary urgency;difficulty starting or stopping urination;weak or interrupted urine flow;painful or burning urination;erectile dysfunction;painful ejaculation;blood in the urine or semen。

Anyone experiencing these symptoms should consult with their doctor as soon as possible. While many other conditions can cause similar symptoms, it is important to rule out prostate cancer.

Once a person has been diagnosed with prostate cancer, the signs of metastasis will vary depending on the where the cancer spreads and how quickly it is growing.

For example, a person with prostate cancer and local metastasis to nearby lymph nodes may not experience any change in symptoms.

However, a person with metastasis to the bones may experience bone pain.

Other symptoms of metastasis may include:fatigue;feeling unwell;reduced appetite;weight loss;swelling in the legs or feet。

Metastatic Prostate Cancer Complications

Advanced prostate cancer can cause many other health problems depending on where the cancer has spread to and how quickly it is spreading.

1) Urinary problems: Cancerous growths can press on the bladder, urethra, or other pelvic organs. Prostate cancer can also spread to those organs and cause urinary retention, blood in the urine, incontinence, and difficulties emptying the bladder.

2) Bowel problems: Advanced prostate cancer can cause bowel problems, such as constipation, diarrhea, urgency, obstruction, and incontinence. This is often due to the use of pain medications, or the spread of prostate cancer to the bowel or rectum. Dietary changes, dehydration, and inactivity can also cause bowel problems.

3) Sexual problems: It is not uncommon for men with advanced prostate cancer to have difficulties getting or maintaining an erection. Some men also have decreased libido or an inability to ejaculate.

4) Bone pain or fractures: Prostate cancer that has spread to the bones can cause significant bone pain. It can also weaken the bones, making a person susceptible to breaks and fractures.

5) Hypercalcemia: Calcium is stored in the bones but can leak out into the blood if prostate cancer spreads to the bones. High levels of calcium in the blood can cause fatigue, increased thirst or need to urinate, nausea and vomiting, constipation, and loss of appetite.

6) Anemia: Anemia means a decrease in the number of red blood cells that are available to carry oxygen throughout the body. This can lead to severe fatigue, shortness of breath, and looking pale. It is usually caused by cancer that has spread to the bone marrow but can also be a side effect of cancer treatments.

7) Lymphedema: Prostate cancer that has spread to the lymph nodes can cause blockages within the vessels that transport lymph around the body. This causes swelling in the legs or scrotum.

Metastatic Prostate Cancer Prognosis

The prognosis for advanced prostate cancer depends on where the cancer has spread and how aggressively it is growing.

According to the American Cancer Society, survival rates are as follows:

1) Local prostate cancer without spread has a 5-year survival rate at nearly 100 percent.

2) Prostate cancer with local spread also has a 5-year survival rate at nearly 100 percent.

3) Prostate cancer with distant metastasis has a 5-year survival rate of around 29 percent.

These are general statistics; it is important for a person with prostate cancer to speak to their doctor about their specific case.

The Metastatic Prostate Cancer Traditional treatments

There are many types of traditional treatments available for advanced prostate cancer. A doctor or oncologist will develop a treatment plan that takes into account the individual's symptoms, prognosis, goals for treatment, age, and general health.

1) Hormone therapy

Hormone therapy for advanced prostate cancer shuts down the production of male sex hormones. This can help prevent the cancer from continuing to grow. Common drugs include abiraterone (Zytiga) and enzalutamide (Xtandi).

2)  Chemotherapy

Chemotherapy is a type of medication that destroys cancer cells or prevents them from multiplying. People are usually given chemotherapy once the prostate cancer has stopped responding to hormone therapy.

Chemotherapy is usually a combination of two or more drugs that are administered intravenously, injected, or taken as a pill.

3)  Immunotherapy

Immunotherapy is a type of medication that modifies the body's immune system to find and destroy cancer cells.

4)  Treatment for prostate cancer that has spread to the bones includes drugs such as zoledronic acid (Zometa) and denosumab (Xgeva).

Treatment for local metastatic cancer may also include radiation therapy.

Side effects of the prostate cancer traditional treatments

Prostate cancer treatment can cause some serious side effects, including:infertility;urinary incontinence;urinary retention;diarrhea;erectile dysfunction;pain;fatigue;hair loss;loss of appetite;nausea and vomiting,etc。

A person should not feel the need to "power through" or suffer from uncomfortable symptoms. It is important for anyone undergoing treatment to communicate with their healthcare team about any side effects they are experiencing.

The Second Part3D Precision & Targeted Therapy on the Latest Theory of Treating Metastatic Prostate Cancer  

Metastatic Prostate Cancer is a systemic disease and its treatment is a systems engineering, it needs the combination of multi-specialty and multi-discipline in theory and practice. In addition, patients should have a full understanding of their own diseases, abandon some traditional misconceptions, avoid the influence of all adverse factors that have carcinogenic effects, including some traditional treatments with many side effects, completely change unhealthy lifestyles, and re-establish and develop healthy internal environment and all positive factors that have anti-cancer effects.

3D Precision & Targeted Therapy in the research and treatment of Metastatic Prostate Cancer has combined with our latest research and the most advanced evidence in the world, and we propose the following new theory of Metastatic Prostate Cancer Treatment.

(I) Proto-oncogene and tumor suppressor genes  

Each person has proto-oncogenes and a tumor suppressor genes in the body, and both the proto-oncogene and the tumor suppressor gene are genes that play an important role in cell growth, proliferation and regulation. A tumor is essentially a genetic disease. Various environmental and genetic carcinogenic factors cause normal cellular DNA damage, thereby activating oncogenes and/or inactivated tumor suppressor genes, plus damage apoptosis-regulating genes, and DNA repairing genes, which are the basis of malignant tumors. 

The proto-oncogene refers to an oncogene that is present in the genome of a biological normal cell. Under normal circumstances, the proto-oncogene is in a low or no expression state and plays an important physiological role. The proteins encoded by proto-oncogene are mostly cell growth factors and growth factor receptors important for normal cell growth, such as PGF, FGF, EGF, TK, STAT, and CDK, etc.  

The tumor suppressor gene is a gene that inhibits cell growth in normal cells and has a potential tumor suppressor effect. The tumor suppressor gene plays a very important negative regulatory role in controlling cell growth, proliferation and differentiation. The tumor suppressor gene and the proto-oncogene restrict each other and maintain the relative stability of the positive and negative regulatory signals.

However, under the action of certain carcinogens, the proto-oncogene can be activated and transformed into an oncogene, which induces the cells to become cancerous. Under the action of carcinogen, when the inactivation of tumor suppressor gene occurs, malignant transformation of cells can be caused, thus leading to the occurrence of tumor.  

There are many types of proto-oncogenes and tumor suppressor genes. The proto-oncogene family includes the ras gene family, the myc gene family, the src gene family, the sis gene family, and the myb gene family. At present, more than 100 kinds of tumor suppressor genes have been discovered, and the most common ones are genes such as Rb, P53, APC and nm23. Therefore, the activation of the different proto-oncogenes and/or the inactivation of the tumor suppressor genes can lead to the occurrence and metastasis of different types of malignant tumors.  

The strength of proto-oncogenes and the power of tumor suppressor genes maintain a balance in good health. However, under the action of carcinogen, the power of proto-oncogenes will become stronger, while the power of tumor suppressor genes will become weaker. The physical, chemical, and biological factors that induce cells to become cancerous are known as the carcinogens. Carcinogen is the "key" to initiate the growth of cancer cells. The more "keys" there are, the greater chance malignant tumors occur and metastasize.

Therefore, targeting the treatment of malignant tumors and metastatic cancer, the multi-site, multiple gene-targeted medicines should be designed to inhibit the proto-oncogenes, activate the tumor suppressor genes, and repair the damaged apoptosis-regulating genes and DNA repair genes. In this regard, some studies have demonstrated that natural herbal extracts have a very safe gene-targeted therapeutic effect.  

In addition, we still have to eliminate various carcinogens as much as possible, inhibit carcinogenicity in vivo, and actively develop anti-cancer ability in the body. This includes conditioning of mental factors, nutritional and healthy diets, and lifestyle changes, etc.

(II) Androgen-dependent tumor

The prostate is an androgen-sensitive organ, so its growth and functional maintenance require proper androgen in the blood. Testosterone is the main androgen in the blood circulation, which is converted to more physiologically active (DHT) by the 5a-reductase in the prostate. (DHT) is the main androgen for prostate growth. Under the influence of some pathogenic factors, if the prostate is blocked, the accumulation of DHT in the prostate can promote the enlargement of the prostate, causing benign prostatic hyperplasia and prostate cancer.

At present, there are a large number of clinical studies in the world that prove (1) patients with prostate cancer are at low androgen levels; (2) when blood testosterone (normally 15nmol/L) or free testosterone index (normally 4.0) is lower than normal level, the incidence of prostate cancer may increase. Low androgen levels in patients with prostate cancer often suggest a poor clinical outcome.

Prostate cancer patients are at low androgen level. The decrease of free testosterone level may lead to the increase of 5a-reductase activity and increase the conversion rate of testosterone to (DHT), thus increasing the risk of metastatic prostate cancer.

Therefore, patients with prostate cancer may be at low testosterone levels and high (DHT) levels. The main evidence in this regard is that (1) patients with familial hereditary 5a-reductase deficiency never develop BPH and prostate cancer; (2) Asian Americans with low risk of prostate cancer have higher serum testosterone levels than European Americans with high risk of prostate cancer; (3) Prostate cancer generally occurs in older people, and as the age increases, the level of androgen in the body decreases, and the incidence of prostate cancer will continue to rise.

Currently, for the clinical treatment of metastatic prostate cancer, the traditional method is to use anti-androgen endocrine therapy, and the most commonly used drugs are goserelin and bicalutamide which cause the blood testosterone to a very low level very quickly with such common side effects as sexual dysfunction, osteoporosis, liver function damage, anemia, depression and so on. In the early stage, hormone-dependent prostate cancer (HDPC) can achieve the goal of reducing tumors and decreasing blood PSA through endocrine therapy. However, after 1 to 2 years of treatment, it gradually evolves into hormone-independent  prostate cancer (HIPC), which leads to the patient's death from extensive metastasis of cancer cells. 

Anti-androgen therapy makes patients’ androgen at a lower level, and causes anemia, nutrient deficiencies, mental depression, decreased immunity, osteoporosis prone to fractures and many other side effects, and ultimately leads to death from extensive metastasis of cancer cells. Therefore, we oppose the use of longer-term anti-androgen endocrine therapy.

On the basis of maintaining normal levels of blood testosterone (normally 15 nmol/L), we recommend that patients use a 5a-reductase inhibitor for longer periods of time to reduce (DHT) levels in the prostate and metastatic lesions, make the growth of cancer cells lack nutrients, which can achieve the goal of inhibit and shrink tumors and reduce blood PSA. Long-term use of chemically synthesized 5a-reductase inhibitors also has many side effects. We recommend that patients use herbal extract 5a-reductase inhibitors of natural origin without any side effects even after the long-time use.

(III) Tumor microenvironment - "seeds and soil"   

As early as more than 100 years ago, the famous pathologist Stephen Paget proposed the concept of "seed (cancer cells) and soil (internal environment)" for the occurrence and metastasis of tumors. It has not received enough attention from the medical community, and its treatment thinking has only confined to the tumor cells themselves, causing humans' treatment roads towards tumors extremely difficult. Until recently, oncologists began to realize that tumors and the internal environment are an inseparable whole. The tumor microenvironment is the internal environment in which tumor cells are produced and lived, including not only the tumor cells themselves, but also various cells such as fibroblasts, immune and inflammatory cells, glial cells, etc.. At the same time, it also includes the interstitial cells, microvessels, and biomolecules infiltrated therein in the nearby areas.

The internal environment of the human body is mainly composed of micro-ecological balance, nutrient metabolism balance and immune balance. For cancer patients, these three balances are all unbalanced.

There are many differences between the physical and chemical properties of the tumor microenvironment and the normal internal environment of the human body. The most obvious features are hypoxia, low PH, and high interstitial pressure. (1) Hypoxic environment: There are hypoxic states in many malignant tumor tissues, and necrosis often occurs in hypoxic regions, in which tumor spread and metastasis are more likely to occur. (2) Low PH environment: The low PH of the tumor microenvironment is on the one hand, in the case of hypoxia and a large amount of glucose decomposition, glycolysis produces a large amount of lactic acid and causes a decrease in PH. On the other hand, there are many kinds of ion exchangers on the membrane system of tumor cells, which play an important role in establishing the acidic environment of the tumor microenvironment. (3) High-pressure environment: Due to the lack of functional lymphatic system in tumor tissue, tumor vascular dysplasia leads to hypertonic vascularization, which eventually leads to tumor interstitial high-pressure.   

It is precisely because of these characteristics that there are a large number of immunoinflammatory reactions produced by growth factors, cell chemokines and various proteolytic enzymes in the tumor microenvironment. This property is very conducive to tumor proliferation, invasion and adhesion, angiogenesis, and anti-radiotherapy and anti-chemotherapy, promote the occurrence of malignant tumor metastasis. Such physical and chemical characteristics as hypoxia, low PH and high pressure, they are not compatible with the normal environment, but tumor cells can adapt well through various biological adjustments, and this adaptation of tumor cells often leads to a vicious circle.

According to the theory of tumor microenvironment, we design a new idea for treating tumors:   

The tumor microenvironment is a complex system, and we need to understand the effects of the entire microenvironment on the occurrence, development, and metastasis of tumors. In terms of treatment design, we can first take natural herbal medicines therapy to restore the internal environment balance of the human body, correct the tumor microenvironment of hypoxia, low pH and high pressure, and cut off the connection between the tumor microenvironment and tumor cells. In addition, we should design multi-site and multi-target herbal treatment medicines, not only to consider the tumor cells as "seeds", but also to consider the tumor microenvironment as "soil", through which it is possible to obtain the better therapeutic effects and lower the toxic side effects.

 (IV) Relationships between chronic inflammation and tumor 

Inflammation is a defense response of the body to bad stimuli. Chronic inflammation refers to the inflammation process lasting more than 3 months.

Any factor that causes tissue damage can be the cause of inflammation, that is, the inflammatory agent. Depending on the different inflammatory factors, inflammation can be divided into infectious inflammation and non-infectious inflammation. Infectious inflammation is caused by a variety of biological pathogens, including bacteria, viruses, chlamydia, mycoplasma, fungi, spirochetes, and parasites. While the non-infectious inflammation is mainly caused by physical factors, chemical factors, and immune responses.

In recent years, more and more research evidence indicates that tumor occurrence and metastasis have a very close relationship with chronic inflammation. From a certain perspective, cancer is also a chronic inflammatory disease. The traditional immunology believes that immune cells help the body fight harmful invaders and thus exert effective anti-tumor functions. However, in the actual development of tumors, some immune cells often change from the "protector" of the internal environment to the "accomplice" of tumor cells, promoting and nourishing the development of tumors. When tumors become malignant, many inflammatory immune cells are released into the tumor microenvironment for participation and regulation, in which macrophages, neutrophils, mast cells and so on play an important role. They release chemical chemotactic factors, vascular growth factors and matrix degrading enzymes, which are beneficial to tumor growth, invasion and metastasis. In addition, these immune cells continue to produce peroxynitrite, a cell DNA damaging agent that is highly susceptible to genetic mutations, activates cellular oncogene, and continuously produces new cancer cells.

For the relationship between infectious inflammation and cancer, it is just like that of hepatitis virus and liver cancer, EB virus and nasopharyngeal cancer, HPV and cervical cancer, Helicobacter pylori and gastric cancer, Streptococcus Bovis and rectal cancer, and the like. For the relationship between non-infectious inflammation and cancer, it is just like ulcerative colitis of immune diseases leading to colon cancer, long-term smoking to respiratory inflammation and tumor, long-term drinking to digestive tract inflammation and tumor, and so on. There are also relationships between many undiscovered inflammations and cancer. For example, the recent research suggests that Escherichia coli, Staphylococcus epidermidis, and human cytomegalovirus (HCMV) are closely related to the development and metastasis of breast cancer.  

Even more studies have shown that patients with extended-range cancer surgery, overdose of chemotherapy and radiotherapy, will produce inflammation at the more parts of the body, and are more likely to have metastatic cancer occurred at multiple parts.    

We have also found in clinical treatment that all prostate cancer patients have had inflammation in the prostatic fluid, and the degree of inflammation is proportional to the extent of the tumor. And in patients who have undergone prostate biopsy, the degree of inflammation in the prostatic fluid is also significant.

In addition, inflammation can also affect the treatment of tumors and the prognosis, recurrence and metastasis of tumors. Therefore, for the cancer treatment program, it needs to consider the inflammation and immune factors of human body. If the relationship between various tumors and inflammation can be clarified, anti-inflammatory drugs are often used which can completely prevent and control the development and metastasis of tumors. However, long-term use of chemically synthesized anti-inflammatory drugs such as adreno cortico hormones and antibiotics can cause many side effects and is detrimental to tumor control. Patients are recommended to use natural anti-inflammatory herbal extracts.

The Third Part:How does 3D Precision & Targeted Therapy Treat Metastatic Prostate Cancer

Survival with tumor is the goal of long-term survival of patients with advanced cancer, which is currently the main research direction of the medical community. Survival with tumor is that the common cancerous symptoms get reduced or disappeared, the local tumor volume is further shrunk without the cancer cells spreading,cancer is in a stable state for a long time, the patient is generally in good condition, and can work independently and life after the patient's overall effective anti-tumor treatment. When the body's ability to inhibit tumors continues to be greater than the ability of tumor growth and proliferation, cancer cells are "quiet" and "dormant" for a long time, and the patient is in a healthy state of long-term survival with tumors. Survival with tumor can only be achieved by relying on the systemically effective anti-tumor treatment in combination with the local treatment.

The goals of 3D Precision & Targeted Treatment metastatic prostate cancer are to:

1) Reduce and eliminate your symptoms, shrink the tumor.

2) You may remain survival with tumor for a longer time than the average that was found in various traditional treatments.

3) Prostate cancer with distant metastasis has a 5-year survival rate of around 90% from the current traditional treatment of around 29%.

3D Precision & Targeted Therapy uses a systematic systems engineering to treat metastatic prostate cancer. Patients can receive all or part of the medical services under the guidance of the doctor based on their conditions.

We provide the following medical services:

1) A thorough treatment of intraprostatic tumors in a very safe and non-side effect way

3D prostate cancer precision & targeted local injection technique and anti-cancer herbal medicines are used to kill all cancer cells in the prostate, thoroughly treat intraprostatic tumors, make them no longer release cancer cells into the spreading and metastatic channels.

At present, for cancer patients with prostatic excretory ducts not destroyed, 3D Prostate Precision & Targeted Treatment can significantly reduce or completely eliminate tumors by killing cancer cells, decomposing tumors, and expelling tumor material. However, for cancer patients with prostate excretory ducts have been destroyed, the tumor continue to exist after treatment even after killing cancer cells, decomposing tumor, because tumor substances unable to be discharged. But the tumor will not continue to develop.

We recommend that you make arrangements to come to our 3D Prostate Clinic in China for a period of 4-6 weeks’ treatment.

2) An oral natural anti-cancer herbal medicine is appropriate for the metastatic cancer condition, and has no side effect nor adverse reactions. This natural anti-cancer herbal medicine consists of various herbs extracts, which contains a variety of bioactive components interacted specifically with cancer cells. The studies have shown that they have anti-cancer effects on multiple sites and multiple target points, such as inhibiting the activity of 5a-reductase and proto-oncogenes, activating the activity of tumor suppressor genes, and repairing the damaged Apoptosis regulatory genes and DNA repairing genes, etc. so that you can treat your cancer at home.

We recommend that patients can take this oral anti-cancer product of multi-site and multi-target point for a long term, until the metastatic cancer has been well controlled, and the patient is in a healthy survival condition with tumor.

3) An oral natural anti-inflammatory herbal medicine that is appropriate for any inflammatory condition, and has no side effect nor adverse reactions. This natural anti-inflammatory herbal medicine consists of various herbs extracts, which contains a variety of the interacted anti-inflammatory bioactive components. The studies have shown that they have significant therapeutic effects on various infectious inflammation and non-infectious inflammation, and can alleviate or eliminate the symptoms of fever and pain caused by metastatic cancer. In addition, this natural anti-inflammatory herbal medicine also has such significant functions as anti-oxidation, discharging toxins from the body and enhancing immunity, and it has a certain preventive effect on tumor occurrence and metastasis.

We recommend that patients take natural anti-inflammatory herbal medicine for 3-6 months.

4) An oral natural herbal medicine for tumor microenvironment regulation, which has no side effect nor adverse reactions. This natural regulatory tumor microenvironment herbal medicine consists of various herbs extracts that contains a variety of the interacted regulatory tumor microenvironment bioactive components. The studies have shown that they can improve the internal environment of cancer patients, correct cancerous constitution, make tumor microenvironment of hypoxia, low PH and high pressure better, and have certain auxiliary therapeutic effects on tumor occurrence and metastasis.

We recommend that patients take this natural regulatory tumor microenvironment herbal medicine for 3-6 months.

5) Other treatments:

 (1) Treatment of chronic diseases: Instruct patients to actively treat chronic diseases associated with cancer and metastatic cancer, such as chronic infection, diabetes, hyperlipidemia, obesity, kidney disease, etc.

 (2) Treatment of tumors at the metastatic site: Different treatments are taken for the characteristics of tumors at different metastatic sites. For example, patients with bone metastases are advised to take oral botanical medicines for preventing bone destruction and hematopoietic cells supplementation, because cancer cells in the bone marrow will destroy sclerotin and hematopoietic cells that can easily lead to fractures and anemia. These patients are not recommended for endocrine hormone therapy as it is more likely to cause fractures and anemia.

 (3) Treatment of metastatic cancer and complications: Metastatic cancer at different sites and at different stages produces different symptoms and complications that require symptomatic treatment. The most serious complications are anemia, edema, and thrombosis. The situation will cause organism ischemia, hypoxia, acidosis, and hypoproteinemia, which will worsen the microenvironment of the tumor and cause extensive metastasis of cancer cells. Patients with severe complications often have a poor prognosis with very low 5-year survival rate. The patients with metastatic cancer are firstly to prevent the occurrence of these serious complications, but if it occurs, they need to receive active professional treatment.

 (4) Other palliative treatment: For example, targeting tumor compression nerves, blood vessels, and other important lumens, the palliative surgery or radiotherapy are used to reduce tumors and relieve pressure symptom. Others include psychotherapy, natural therapy, etc.

Minimizing the Effects of Metastatic Prostate Cancer

As a sufferer of metastatic prostate cancer, there are some significant things you can do to minimize the effects of metastatic prostate cancer until you are a member of our 3D clinic's family for successful treatment.

1) Maintain some safe and reasonable treatments and medicines without side effects. Avoid treatment that is unfavorable to metastatic cancer as much as possible, including toxic medicines or drugs with great side effects, excessive surgery, radiation therapy, and chemotherapy, etc.

2) Maintain your psychological health: Psychological tension and excessive mental stress are catalysts for the occurrence and metastasis of cancer cells in the body. Stress and excessive excitement and depression can lead to the elevated levels of adrenocortical hormones, which can reduce the body's immunity and are vulnerable to various diseases including cancer. Cancer patients who receive psychotherapy during their illness and are often encouraged by the positive spirits of their relatives and friends generally obtain excellent treatment results.

3) Maintain aerobic exercise everyday: Exercise causes the human body to inhale oxygen several times to several tens of times more than usual. Usually when people is quiet, the oxygen intake is 4-7 liters per minute, while doing the exercise, it can reach more than 100 liters. The increase in oxygen uptake and the frequent exchange of gases can cause some carcinogens in the body to be excreted; in addition, it can also better change the hypoxia microenvironment of tumor in vivo.

In addition, patients can also change the microenvironment of tumor growth in vivo by drinking Ozone water generated by machine and inhaling negative Ion Air.

4) Maintain a good sleep: At night, a melatonin is produced in the body, and the property of its antioxidant protects the normal cellular DNA from the damage caused by carcinogens in the body. It also inhibits the production of estrogen which promotes the growth and development of certain tumors.

5) Maintain a reasonable dietary structure: according to the World Health Organization, 30% to 40% of male cancers and 60% of female cancers are related to diet. People need to eat yellow and green vegetables, fruits, foods rich in vitamins and carbohydrates. Pay attention to reduce high-salt foods. Eat less pickled and marinated food. Avoid moldy foods. Pay attention to avoid high-fat diet, and fat intake should be controlled below 30% of the total daily calories. High-fat diets and obesity can cause endocrine hormone disorders, which are associated with male prostate cancer and female breast cancer.

6) Maintain a healthy lifestyle: Changing the bad habits and maintaining a healthy lifestyle is the most economical and effective way to prevent the occurrence and metastatic of cancer.

Experts put forward 10 proposals for preventing cancer through reasonable living and eating habits:

 (1) Stop smoking, do not drink alcohol, or restrict alcohol.

 (2) Avoid excessive sun exposure.

 (3) Encourage to do physical activity, adhere to physical exercise, and avoid obesity.

(4) Open mind, not sulking, keep a good mood.

 (5) Hold on to the grain, cereals, beans, sweet potatoes as the main staple foods, and have crude and fine fiber foods properly matched.

 (6) Reduce meat intake and avoid animal fat.

 (7) Eat more fresh vegetables and fruits with vitamins A, C, and E that can reduce the risk of many common cancers, especially dark leafy vegetables and carrots and tomatoes.

 (8) Food storage should be mildewproof and do not eat moldy food.

 (9) The cooking method should be scientific, eat less salt and pickled food, do not eat smoked, fired, fried, charred and over-hot food.

 (10) Protect the environmental health and reduce indoor and outdoor air pollution.


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